Sample
Scroll through a complete example below. It has the same areas, and the same care, as the one we would prepare for you. Identifying details have been removed from this example.
What it covers
The example includes a reading guide, a summary, the findings in each area and suggested next steps. It also includes the methods and limitations. Your report will depend on your results and the information you share.
On scope
This analysis is informational and educational, not a medical diagnosis. The pharmacogenomic, carrier and biomarker pages are written as starting points to bring to your physician, and anything of clinical consequence is flagged for you to take to them. This example comes from a DNA array. You can choose to go deeper, with whole-genome sequencing, which covers your whole genome about thirty times over. It reaches the rare, high-impact and structural variants (larger rearrangements of DNA) an array cannot see, plus fuller drug-response detail. Whichever depth you choose, the same scientist examines your results and writes what you see here. The areas in this example are written the same way at both depths, and the genome puts more underneath each one.
DNA Array · Advanced Biomarkers · Analyst Interpretation
HG-SAMPLE
Confidential · Genotype-imputed polygenic assessment · Not a diagnostic test
Contents
About this assessment
This is a genotype-based assessment: the DNA is read on an array, imputed to millions of markers, and combined into polygenic risk scores (PRS): a single number summarizing how thousands of variants nudge predisposition up or down relative to a reference population. A high percentile means a stronger genetic tendency, not a diagnosis. Most findings are modifiable through screening and lifestyle. Because it reads common, well-studied variants, not the whole genome, it cannot see rare or structural variants; the complete read is the whole-genome depth of a Precision Longevity Analysis, at helixirgenomics.com/array-vs-whole-genome.
Sample's results in plain language: the findings that matter, and what to do about them.
This person presents an athletic, low-cardiometabolic-risk genetic baseline. Across 1,300+ polygenic outcomes the great majority are typical or favorable. The screen surfaces a small number of high-signal findings worth acting on, and several that simply confirm choices already made.
Top findings
Lead finding, colorectal predisposition
Top-decile polygenic score, compounded by reported family history. This is the report's primary actionable item: it moves screening earlier than population guidelines.
Favorable cardiovascular aging
Lower-tertile coronary-risk score, consistent with this person's training load and in-range lipid panel.
Pharmacogenomic note
A genotype associated with favorable lithium response, relevant to continuity of psychiatric care.
What to do, in order
A polygenic screen across age-related conditions. For each, your combined genetic signal is compared with a reference population, and we flag where your lifetime predisposition is elevated. These are probabilities, not diagnoses, most are modifiable.
4 elevated56 favorable or typical
Favorable across Cardiovascular aging · Type 2 diabetes · Inflammatory set-point · Bone density.
Elevated lifetime predisposition. Screening (colonoscopy) is highly effective and brings this back into a manageable range.
Genetic tendency toward hypertension with age. Currently well-controlled by training load; worth periodic monitoring.
Higher predisposition to melanoma. Annual dermatology skin checks and sun protection are the key levers.
Also assessed · scores in the typical range
Alzheimer's Disease
Asthma
Atrial Fibrillation
Bipolar Disorder
Cardiovascular Disease
Celiac Disease
Coronary Artery Disease
Crohn's Disease
Multiple Sclerosis
Osteoporosis
Parkinson's Disease
Rheumatoid Arthritis
Stroke
Type 2 Diabetes
Every finding with a clear next step, in one place. Some rest on many variants at once, others on a single gene. Genetic predisposition is one input among many, and both screening and everyday habits can change how things turn out.
Top 8% polygenic risk, compounded by reported family history.
Associated step · Earlier and more frequent colonoscopy screening.
High polygenic load for melanoma.
Associated step · Annual full-skin dermatology review; daily SPF.
Share these pages with anyone about to prescribe for Sample. The groups separate prescribing considerations from additional findings and coverage limits. The results need clinical interpretation before changing treatment.
Genotype associated with favorable response.
Normal metabolizer, standard dosing expected.
How this genotype is associated with handling some medicines; worth sharing this page with a prescriber before any changes.
Bloodwork measured on your own sample, positioned against reference ranges. Genetics shows predisposition; labs show your current biological state.
Liver
Ref 8–61
Cardiometabolic
Inflammation
Micronutrients
Ref 30–60
Carrier screening looks for variants linked to inherited conditions. For most autosomal recessive conditions, a child is at risk when both parents carry a disease-causing variant in the same gene. X-linked conditions follow different inheritance patterns. Each finding explains the relevant inheritance and any implications for your own health.
Recessive conditions screened · not detected
Canavan Disease
Familial Mediterranean Fever
Gaucher Disease Type 1
Tay-Sachs Disease
Sickle Cell Anemia
Beta-Thalassemia and Related Hemoglobinopathies
Pompe Disease
Phenylketonuria and Related Disorders
MCAD Deficiency
Maple Syrup Urine Disease Type 1B
Niemann-Pick Disease Type 1A
Usher Syndrome Type 3A
Glycogen Storage Disease Type Ia
Pyruvate Kinase Deficiency
Other inherited conditions · not detected
Calls from Sample’s own array. Worth a word with a physician if family planning is on the horizon.
Sample's genetic ancestry, estimated from markers spread across the whole genome and shown as the parts of the world they are most common in. This is heritage rather than health: a window into the long path that carried this DNA down the generations, with no bearing on disease risk.
Ancestry & Lineage · the direct lines
The percentages above mix every ancestor together. These do not: each follows a single line of descent back through the generations unbroken, because the DNA they read is passed down one parent at a time and barely changes on the way.
Maternal lineage · mtDNA
Haplogroup H1
Western Europe · ~10,000–15,000 years ago
Heritage, not health: a deep-history marker, with no bearing on disease risk or medical guidance.
ε3/ε3
Typical
Two ε3 alleles, the most common genotype, neither protective ε2 nor risk-raising ε4.
Behavioral and sensory tendencies with a partial genetic component. These are traits, not medical findings: included for context and interest, not action.
Higher genetic pull toward sweet foods.
Genetically inclined to wake and perform earlier in the day.
Favorable VO₂-max trainability profile.
The genetics of muscle type, recovery, injury risk and how the body responds to exercise. These are tendencies; training and recovery remain highly modifiable.
Muscle profile
Power-leaning
ACTN3, a power/strength-leaning muscle profile.
Typical muscle-recovery genetics.
Average metabolic response to training.
Strength training suits this profile.
Nutrigenomics: caffeine and alcohol handling, macronutrient leanings, blood-sugar genes and specific nutrient needs. These shape diet and the supplement formula that follows.
Fast metabolizer, low jitter risk.
Carries a permissive HLA-DQ8 type. Most carriers never develop celiac, and overall risk is normal. Genetics alone cannot exclude it.
Lactase-persistent (MCM6 / LCT), digests dairy comfortably.
Salt-sensitive, keep sodium moderate.
Keep sodium moderate. Caffeine and dairy need no change, and the gluten note is context, not a restriction.
Supplement topics reviewed alongside Sample's genetics, bloodwork and history. Inclusion does not establish a deficiency or a need for treatment. Review the reason and limitations for each item before changing supplements.
Synergistic cofactors
Built for this person from their genetics, bloodwork and history. Each supplement carries the main reason it's here, a polygenic nutrient need (PRS), a specific gene (Gene), a need confirmed by bloodwork (Lab), or added for synergy (Cofactor).
Your Formula · clinician notes & safety
Evidence-based cautions on this specific stack, given everything else in these results. The formula is a personalized starting point to review with a physician or pharmacist; these notes are for that conversation, not self-medication.
Doses here are starting points reasoned for this individual rather than taken from a fixed list. They are informational, not a prescription.
Any supplement–medication interaction is flagged for you to confirm with your own physician before starting.
Nothing here is a prescription. Supplement doses, forms and combinations (and any interaction with prescription medication) should be confirmed with a physician or pharmacist before starting.
Appendix · Methodology & limitations
DNA was genotyped on an array and statistically imputed to millions of variants. Disease and trait predispositions are expressed as polygenic risk scores (weighted sums of many variants) reported as percentiles against a reference population. Carrier, pharmacogenomic, APOE and ancestry results use direct genotype calls. The findings are then considered together. Where a broad view of someone’s longevity and a single score point in different directions, the broader view is favored. A scientist went through every section for the individual.
Limitations
Sample HG-SAMPLE · Coordinates on GRCh38
Prepared by
Adriano De Marino, PhD
Precision medicine analyst · Helixir Genomics
Not a physician. No physician has reviewed or signed this report.
How it arrives
You receive two things: a book, printed on heavy paper and bound in cloth, sent to your door, and a digital edition kept in your account. We make it this way on purpose. It is a record you can come back to as your questions change, not a dashboard you log into once and forget. What it says about you is the point. The binding is simply a place worth keeping it.
Your turn
Your analysis covers the same areas using your results and health information. The findings and recommendations will depend on what those results show.