The hand that writes
Adriano De Marino.
Founder of Helixir Genomics and Helixir Health. A precision medicine analyst, someone who reads DNA for a living, with a PhD in precision medicine, genetics and computer science. For over ten years he built tools that read millions of genomes at once. He now reads them one at a time, because the changes that actually help a person live longer come from looking closely at their genome alone.
New York Public Library · Fifth Avenue
Drafting Selphi, a new genotype imputation algorithm for human DNA.
At a glance
- Trained in
- Precision medicine · Genetics · Computer science (PhD)
- Background
- 10+ years across companies in the genetics industry, variant interpretation, imputation, polygenic risk scores
- At Helixir
- Founder · analyses every Helixir Genomics genome personally
- Not
- A licensed physician, clinical decisions belong to your doctor
The path here
From scale, to one person at a time.
His PhD, in precision medicine, genetics and computer science, ran between Università degli Studi di Milano-Bicocca and the San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) in Milan. The focus was turning a raw genome into something a person can actually use. After that came years at one of the largest consumer genomics platforms in the world, building the software that reads DNA at huge scale.
That work was rewarding, and it taught him where the limits sit. Software is very good at spotting what is in your DNA. It is far weaker at telling youwhat it means for you. At that scale, no analysis was truly one person’s own. Every finding had to be written to a template and tuned to an average, so it was never wrong, but rarely useful.
Helixir Genomics is the opposite of that, on purpose. One genome. One scientist. One plan, written for the person whose name is on it. The DNA and the science behind it are the same as anywhere else; the close, personal reading is what changes.
Credentials
- DoctoratePhD · Precision medicine, Genetics, and Computer science
Università degli Studi di Milano-Bicocca · San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), Milan - Industry10+ years across companies in the genetics industry
Variant interpretation · imputation · polygenic risk scores · ancestry inference
Selected publications
Peer-reviewed research on reading DNA, weighing genetic risk and tracing ancestry. The same methods sit behind every analysis written here.
- 2025
Optimization of multi-ancestry polygenic risk score disease prediction models
Lerga-Jaso J, Terpolovsky A, Novković B, … De Marino A, … Yazdi PG
Scientific Reports · doi:10.1038/s41598-025-02903-1
- 2025
Tracing human genetic histories and natural selection with precise local ancestry inference
Lerga-Jaso J, Novković B, Unnikrishnan D, … De Marino A, … Yazdi PG
Nature Communications · doi:10.1038/s41467-025-59936-3
- 2023
Selphi: empowering GWAS discovery through enhanced genotype imputation
De Marino A, Mahmoud AA, Bohn S, et al.
medRxiv (preprint)
- 2022
A comparative analysis of current phasing and imputation software
De Marino A, Mahmoud AA, Bose M, et al.
PLOS ONE · doi:10.1371/journal.pone.0260177
- 2022
Prioritization of putatively detrimental variants in euploid miscarriages
Buonaiuto S, Di Biase I, Aleotti V, et al. (De Marino A)
Scientific Reports · doi:10.1038/s41598-022-05737-3
- 2017
Spermatogenic cycle and steroidogenic control of spermatogenesis in Mytilus galloprovincialis
Prisco M, Agnese M, De Marino A, Andreuccetti P, Rosati L
The Anatomical Record · doi:10.1002/ar.23626
A note
A Precision Medicine Analyst, not a physician.
Adriano is a precision medicine analyst, not a licensed physician. A Helixir Genomics analysis is informational, not clinical. It is written to be read, thought about, and shared with your own doctor. Anything in it that has a clinical consequence belongs in a conversation with a physician. When a finding calls for a doctor to sign off and a bloodwork panel to confirm it, the sister practice, Helixir Health, pairs the same genetic reading with that medical authority.
Write to him
Your genome, analysed by this person.
The one in the photograph. Not a team, not a queue, the same scientist from your first question to your finished analysis.